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Seasonal Clues for Biotech, Natural Gas, MLPs, and Regional Banks

Jay Kaeppel
2026-04-28
Trading is a two-part process: 1) Spot opportunity, 2) Exploit opportunity. Seasonality can be an extremely useful tool for identifying potential opportunities. Herein, we review upcoming clues in biotech, natural gas, MLPs, and regional banks.

Key points:

  • Seasonal trends should not be thought of as "buy" or "sell" signals
  • Seasonal trends should be thought of as "clues" that tell us "When to where for a potential opportunity"
  • With that understanding in mind, traders might consider looking more closely at biotech, natural gas, master limited partnerships, and regional banks for potential trading opportunities

Biotech (IBB) faces a short-term headwind

After a strong rally from April to November 2025, the iShares Nasdaq Biotechnology ETF has traded sideways for 5 months.

The Annual Seasonal Trend chart for IBB still suggests a bullish bias for most of the rest of the year. However, the short-term period from Trading Day of the Year (TDY) #80 through TDY #87 tends to be very challenging for this sector. For 2026, this period extends from April 28th through May 7th.

The chart below displays the hypothetical growth of $1 achieved by holding a long position in IBB only during this period every year since 2002.

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